Oncothermia Journal
Volume 15

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Gy. Vincze, A. Szasz (2015) Critical analysis of the thermodynamics of reaction kinetics. Oncothermia Journal 15:8-30

“Our objective is to show the weakness of the recent thermodynamics of chemical reactions. We show that such a thermodynamic theory of chemical reactions. which could be similar to the generalized Onsager's theory in thermodynamics. is not reality at the moment.”

Seung-Gu Yeo (2015) Definitive radiotherapy with concurrent oncothermia for stage IIIB non-small-cell lung cancer: A case report. Oncothermia Journal 15:31-35

“Hyperthermia enhances the susceptibility of tumors to radiotherapy (RT) and chemotherapy. Oncothermia, also known as electro-hyperthermia. is a new treatment modality developed to overcome the problems of traditional hyperthermia by selectively delivering energy to the malignant tissues. The present s1udy reports the outcome of combined oncothermia and RT in a 75-ycar-old patient with stage IIIB non-small-cell lung cancer ( SCLC).”

Gyula Vincze, Oliver Szasz, Andras Szasz (2015) Generalization of the Thermal Dose of Hyperthermia in Oncology. Oncothermia Journal 15:36-54

“Hyperthermia has been a modality to treat cancer for thousands of years. During this time, intensive efforts are concentrated on determining the dose of the proper treatment, but the dominantly in vitro induced cellular death does not provide enough confidence for the clinical dosing. The cell-death by heat·monotherapy applications in laboratory experiments is difficult to apply in the complementary therapies in clinical applications. The newly developed nanotechnologies offer completely new possibilities in this field as well. Modulated electro-hyperthermia (mEHT, tradename Oncothermia) is a nanoheating technology that has selective effects on membrane rafts and on the transmembrane proteins. This effect is thermal. The thermal action is in nanoscopic range which makes the phenomenon special. Our objective is to show the dose concept on this emerging method.”

Yuk-Wah Tsang, Cheng-Chung Huang, Kai-Lin Yang, Mau-shin Chi, Hsin-Chien Chiang, Yu-Shan Wang, Gabor Andocs, Andras Szasz, Wen-Tyng Li, Kwan-Hwa Chi (2015) Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy. Oncothermia Journal 15:55-66

“Background: The treatment of intratumoral dentritic cells (OCs) commonly fails because it cannot evoke immunity in a poor tumor microenvironment (TME). Modulated electro-hyperthermia (mEHT, trade-name: oncothermia) represents a significant technological advancement in the hyperthermia field, allowing the autofocusing of electromagnetic power on a cell membrane to generate massive apoptosis. This approach turns local immunogenic cancer cell death (apoptosis) into a systemic anti-tumor immune response and may be Implemented by treatment with intratumoral OCs.”

Vincze Gy, Szigeti Gy, Andócs G, Szász A (2015) Nanoheating without Artificial Nanoparticles. Oncothermia Journal 15:67-76

“Our aim is to describe the physical and physiological effects of local modulated electro-hyperthermia (mEHT). The method concentrates on the energy absorption of cluster rafts of the plasma membrane. The targeted cluster contains transmembrane proteins, which can form coherent working voltage-gated ion channels and/or TRP receptors in one domain. This targeting is analogous to nanoparticle heating, except this uses readily available nanoparticles on the cell membrane instead of the artificially placed nano-object to induce selective energy absorption from the outside field. In the discussed non-artificial nanoparticle heating, selectivity is the consequence of the synergy of various interaclions embedded into each other in their effective volume in macro-, micro- and nano-ranges.”

Gabor Andocs, Mati Ur Rehman, Qing-Li Zhao, Edina Papp, Takashi Kondo,, Andras Szasz (2015) Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model. Oncothermia Journal15:77-86

“There are intensive debates about the effects and mechanisms of radiofrequency (RF) hyperthermia in oncology. We theoretically modelled the mechanism of the nanoheating effect of the RF current at the cellular and subcellular level. Then, we experimentally investigated the mechanism of heating in comparison with selective modulated electrohyperthermia and water-bath heating conventional hyperthermia (WHT) using the U937 suspension cell line model. The two heating-processes resulted in different distributions of energy-absorption, causing different mechanisms of the thermal processes. Both of the mechanisms are thermal (fit to Arrhenius plot) but the selectively absorbed energy by the plasma membrane rafts and the cell-cell contacts of the cells results in earlier cell-destruction than in case of unselective homogeneous heating. This thermal effect is used for the characterisation of selective heating. The experimental results clearly support the previous theoretical considerations; the cell killing effect can be realised at lower temperature ranges in the case of the modulated electro-hyperthermia (mEHT, trade-name: oncothermia) method than with WHT.”

Vincze Gy, Szasz A (2015) Reorganization of actin filaments and microtubules by outside electric field. Oncothermia Journal 15:87-93

“A theoretical study of the polymerization process of a cytoskeleton by an outside electric field is presented. We describe the reaction kinetics of polymerization of the cytoskeleton by Einstein"s approximation. The thermodynamic study of the equilibrium constant of the reaction kinetics shows the possibility of the reorganization of the cytoskeleton by the outside electric field. We show an effective stimulation of the polymerization which is connected to the effective value of the electric field and can certainly be modified by modulation of the carrier frequency.”

Tae Sig Jeung, Sun Young Ma, JiHoon Choi, Jeasang Yu, Su Yong Lee, Sangwook Lim (2015) Results of Oncothermia Combined with Operation, Chemotherapy and Radiation Therapy for Primary, Recurrent and Metastatic Sarcoma. Oncothermia Journal 15:94-106

“Sarcomas are relatively rare malignancies; however, their huge variety and shortage of the effective therapies make this disease face huge challenge for oncology. It is recently shown that hyperthermia could be successfully applied even in high-risk cases in combination with the available gold-standard regiments. Our aim is to present various advanced cases treated with a new hyperthermia method, oncothermia, showing its advantages and feasibility to successfully treat highly advanced sarcomas with curative intent.”

Sun Young Lee, Min-Gul Kim (2015) The effect of modulated electro-hyperthermia on the pharmacokinetic properties of nefopam in healthy volunteers: A randomized, single-dose, crossover open-label study. Oncothermia Journal 15:107-113

“Purpose: Nefopam is a widely available analgesic for the management of pain. The aim of this study was to reveal Jhe effect of regional hyperthermia of the abdominal area on the pharmacokinelics of nefopam. Materials and methods: A randomised. single-dose. crossover. open-label study was conducted to reveal the effect of hyperthermia using modulated electro·hyperthermia on the pharmacokinetics of nefopam.”

Doo Yun Lee, Joon Seok Park, Hae Chul Jung, Eun Seoul Byun, Seok Jin Haam, Sung Soo Lee (2015) The Outcome of the Chemotherapy and Oncothermia for Far Advanced Adenocarcinoma of the Lung: Case Reports of Four Patients. Oncothermia Journal 15:114-121

“Lung cancer is one of the most aggressive and lethal form of cancers. Patients with far advanced lung cancer are treated by chemotherapy with or without radiotherapy. However, median survival of these patients is less than 6 months. To increase survival and quality of life for these patients, various forms of complementary treatments have been tried in clinical practices, and oncothermia is supposed to be one of the promising candidates. From May 2008 to November 2013, 4 patients with far advanced lung adenocarcinoma (stages IIIB and IV) were treated with oncothermia in addition to conventional chemotherapy at Gangnam Severance Hospital and Bundang CHA Hospital. All these patients have survived for more than 2 years.”